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Panama runs a phased mandatory e-invoicing regime through the SFEP system operated by the Dirección General de Ingresos, in force since 2022. Issuance is mandatory for all supplies to public bodies, while B2B and B2C transactions are brought into scope progressively, using XML and a PDF visualisation with QR.
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The Dirección General de Ingresos issued Resolution 201-6299 of 29 July 2025 updating technical and procedural rules for the Sistema de Facturación Electrónica de Panamá (SFEP), refining issuer obligations, validation behaviour and adoption deadlines for taxpayers operating under the centralized clearance model established by Law 256 of 2021.